Comprehensive analysis of the systemic immune landscape across breast cancer subtypes and disease stages.

This increase in TNFα was statistically significant in patients with HR-positive and TNBC subtypes, and showed a trend toward significance in HER2-positive patients ( Figure 5 C).

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Though no statistically significant difference was observed between patients with early-stage and patients with late-stage breast cancer when all subtypes were grouped together in neutrophil and monocyte counts, we did observe an increasing trend, suggesting that neutrophil and monocyte numbers are being increasingly dysregulated as disease progresses ( Figure 2 A and B).

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