Dose-dependent modulation of hepatic cytochrome P450 enzymes by tenvermectin: implications for medication safety and combination therapy.

p < 0.05 was considered significant, p < 0.01 was very significant, and p < 0.001 was extremely significant. 3 Results 3.1 Substrate conversion assays In order to quantitatively assess the effects of TVM on the activities of key CYPs, HPLC and HPLC-MS/MS analytical methods based on the principle of substrate conversion assay were developed for the quantitative determination of the metabolites (resorufin, 4'-hydroxydiclofenac, dextrorphan and 6β-hydroxytestosterone).

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