SGLT-2 Inhibitors Are Potent to Suppress Aggressive Transformation From Indolent Type of Adult T-Cell Leukemia/Lymphoma: Unique Insight Into Therapeutics for Diabetes-Related Hematological Malignancy.

EJHaem · 2025 · PMC12416307 · PMID 40927635

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an apparent trendno p-value reported

ATL cells showed an apparent trend to decrease nucleosome occupancy in the promotor region of the SGLT‐2 gene.

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an overall trendno p-value reported

In nucleosome occupancy analyses in the promotor region of SLC5A2 , cells from aggressive ATL of patients showed an overall trend to decrease the occupancy in the promotor region as compared to healthy PBMCs, raising a possible involvement of epigenetic dysregulation of SLC5A2 (Figure 2 ).

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