Barely Significant
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Global burden of head and neck cancer from 1990 to 2021: A comprehensive analysis and projections to 2030 based on the global burden of disease study 2021.

PLoS One · 2025 · PMC12416713 · PMID 40920654

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a decreasing trendno p-value reported
LC (Larynx cancer) demonstrated a decreasing trend in ASIR, with an EAPC of −0.28 (95% CI: −0.34 to −0.22).

also in 47,180 other papers

an increasing trendno p-value reported
OPC, as the exclusive HNC subtype, demonstrated an increasing trend in ASDR, with an EAPC of 0.04 (95% CI: −0.07 to 0.15).

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.