Intrauterine hyperglycemia impairs mouse primordial germ cell development and fertility by sex-specific epigenetic reprogramming interference.

Cell Discov · 2025 · PMC12417548 · PMID 40921762

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marginal significanceno p-value reported

In male PGCs, the expression of major DNA methylation enzymes remained largely unchanged, except for a modest decrease in Dnmt3a ( P = 0.07) and slight upregulation of Tet1/2/3 , especially Tet1 with marginal significance (Supplementary Fig.

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