Regiodivergent Lewis acid catalysis of bicyclo[1.1.0]butanes with 2-naphthols.

Introduction The benzene ring is a highly significant structural motif in drug molecules, present in approximately 45% of marketed small-molecule drugs, and can be readily transformed into a variety of functionalized two-dimensional (2D) scaffolds. 1–3 However, it has been found that the benzene ring is still associated with limitations in terms of so

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