− ,, Hence, histone variant PTMs have been explored as obvious diagnostic biomarkers and pivotal predictors for cancer development and prognosis, substantiated by the highly significant correlation between global histone modification patterns, tumor biomarker phenotypes, and patient clinical outcomes. ,− Among the most well-characterized PTMs that affect chromatin structure and function is histone methylation.
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The Identification by Shotgun Proteomics with High-Resolution Tandem Mass-Spectrometry of Histone Isoforms' Hypermethylation Phenotype as a Hallmark Characteristic of Human-IDH-Mutant High-Grade Gliomas: Epigenetic Applications for Genotoxicity-Based Biomarkers and Cancer Therapy Targets.
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