Assessing Stages of Objective Memory Impairment and neuroimaging as risk factors of incident cognitive impairment.

J Int Neuropsychol Soc · 2025 · PMC12418808 · PMID 40842062

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0640

boldest claim

The sentences

highly significantp = 0.001actually significant

Entorhinal thickness was highly significant (HR = 0.57, CI = 0.44 – 0.74, p = 0.001 after correction), representing the strongest biomarker association observed.

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a trend towards significancep = 0.055so close (0.05 < p ≤ 0.1)

showed a trendp = 0.055so close (0.05 < p ≤ 0.1)

Among the FDG-PET biomarkers, entorhinal FDG-PET showed a trend towards significance (HR = 0.62, CI = 0.42 – 0.92, p = 0.055 after correction).

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marginally significantp = 0.063so close (0.05 < p ≤ 0.1)

SOMI-1 and SOMI-2 remained marginally significant ( p = 0.063 for both) after correction.

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a trend toward significancep = 0.064so close (0.05 < p ≤ 0.1)

Partial likelihood ratio tests showed that adding PiB-PET did not significantly improve model fit in either analysis (SD = 1: χ 2 = 0.973, p = 0.324; SD = 2: χ 2 = 1.014, p = 0.314), while adding hippocampal volume showed a trend toward significance in the SD = 2 analysis (χ 2 = 3.428, p = 0.064).

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did not achieve significanceno p-value reported

SOMI-1 showed hazard ratios ranging from 2.97 to 3.95 across models but did not achieve significance after multiple testing correction ( p -values ranging from 0.096 to 0.121 after correction).

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