Natural variability and the influence of concurrent control values on the detection and interpretation of low-dose or weak endocrine toxicities.

Thus, the response to 4MBC was highly significant (p < 0.01) when 19-20- day-old animals were used; this was reduced to p < 0.05 with 20-21-day-old animals, and the response was not significant when the older animals (21-22 and 22-23 days old) were used.

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