Study on the molecular mechanism of matrine in improving rheumatoid arthritis by targeting the NAV2-Wnt3a/β-catenin axis to coordinately regulate the inflammatory-osteolytic loop.

Grayscale analysis ( Figure 5B ) showed that compared to the NOR group, expression of these genes in CIA rat synovial and joint tissues was markedly increased with highly significant differences (p<0.001 for all).

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