Local activity alterations in individuals with autism correlate with neurotransmitter properties and ketamine-induced brain changes.

Nat Commun · 2025 · PMC12420803 · PMID 40925922

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0.0810

closest p · 1.6× alpha

0.0810

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a trend towards significancep = 0.081so close (0.05 < p ≤ 0.1)

We found a significant association between the neurochemical profiles observed for ketamine and autism in ABIDE2 ( r (14) = 0.563, p = 0.023, 95% CI [0.094, 0.828]) and a trend towards significance for ABIDE1 ( r (14) = 0.448, p = 0.081, 95% CI [−0.061, 0.772]) (Fig. 2B ).

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