Importantly, caffeine supplementation resulted in a highly significant increase in the number of motor neurons in WR (Caf) mice at p41 compared to untreated WR animals, suggesting a protective effect of caffeine against motor neuron loss (Fig. 4 b).
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Caffeine mitigates ROS accumulation and attenuates motor neuron degeneration in the wobbler mouse model of amyotrophic lateral sclerosis.
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