Barely Significant
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The Sex Hormone Precursors Dehydroepiandrosterone (DHEA) and Its Sulfate Ester Form (DHEAS): Molecular Mechanisms and Actions on Human Body.

Int J Mol Sci · 2025 · PMC12429729 · PMID 40943486

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highly significantno p-value reported
While comparing the vaginal pap smears after application of vaginal DHEA, decrease in parabasal cells and increase in superficial cells were highly significant than those with placebo use at all time intervals (from 2 to 12 weeks interval), and the effect was not inferior to the effect of applying the vaginal E2 and conjugated estrogen formulations.

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