Graft function and renal protection with peritransplant systemic dexmedetomidine in kidney and liver recipients: systematic review and meta-analysis of randomized controlled trials.

Int J Surg · 2025 · PMC12430911 · PMID 40505055

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0800

boldest claim

The sentences

borderline significanceP = 0.05actually significant

While the meta-analysis did not confirm an effect on DGF after living donor KT, the subgroup analysis indicated a reduced incidence of DGF in recipients of deceased donor kidney transplants with dexmedetomidine, with borderline significance (RR: 0.52 [0.26–1.01]; P = 0.05; Fig. 1 A).

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a nonsignificant trendP = 0.08so close (0.05 < p ≤ 0.1)

Although Shan et al [ 8 ] reported a nonsignificant trend ( P = 0.08) toward reduced 1-year allograft failure rate in deceased donor kidney recipients after dexmedetomidine intervention, the meta-analysis revealed no disparity in long-term allograft failure (RR: 0.62 [0.03–12.79]; P = 0.75; Fig. 1 C).

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