Focused ultrasound-induced blood-brain barrier opening promotes glioprotective phenotypes in ACSA-II+ murine astrocytes.

Although expressed in only a small percentage of the entire population of hippocampal astrocytes, the upregulation of Wnt3 expression relative to untreated controls indicates a positive trend in favor of increased, astrocyte-mediated neurogenesis in the hippocampus.

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Interestingly however, calculating the percent change in the percent of MOG+ oligodendrocytes in FUS-treated compared to naive animals reveals an interesting trend in the relative effectiveness of astrocytic activation of OPCs in young compared to aged and progressed 3xTg-AD animals.

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