marginally significantP<0.001
Similar results were observed for the RFS analysis; that is, there were significant and marginally significant RFS differences between the predicted high- and low-risk stage I patients in the meta-discovery (log-rank P<0.001; C-index =0.63; Figure S5C ) and integrated meta-validation (log-rank P=0.120, C-index =0.57; Figure S5D ) datasets, respectively.