Structural basis of SIRT2 pre-catalysis NAD<sup>+</sup> binding dynamics and mechanism.

The mechanism is supported by the observed gradual distortion of angle ∠(C4–C3–C7–N8) in pre-catalysis states 1–3 ( Table 2 ), which shows an increasing trend (13.9° → 14.3° → 14.8°), consistent with carboxamide twisting.

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