miR-129-1-3p down-regulation promotes BAG cochaperone 3 (BAG3)-driven pro-fibrotic processes in primary fibroblasts from patients with recessive dystrophic epidermolysis bullosa.

KEGG analysis performed on the predicted targets of the twenty-three up-regulated miRNAs showed a highly significant enrichment of pathways known to be involved in fibrotic processes, comprising TGF-β, MAPK, Hippo, Rap1 and PI3K-AKT signalling (#3, #6, #13, #15 and #19 of the top 20 enriched terms, respectively) ( Fig. 2 C).

also in 132,142 other papers