34 This may be significant for autoimmune disease therapies, as misfolded proteins can trigger endoplasmic reticulum (ER) stress and inflammatory signaling via the unfolded protein response, 35 which is linked to some autoimmune diseases including RA 36 and Sjögren’s syndrome. 37 Amplifying ER stress in these contexts may have severe negative consequences.
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Harnessing mRNA-lipid nanoparticles as innovative therapies for autoimmune diseases.
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