The TREM2 H157Y variant is associated with more severe neurodegeneration in Alzheimer's disease and altered immune-related processes.

Alzheimers Dement · 2025 · PMC12441928 · PMID 40960087

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0.0510

closest p · 1.0× alpha

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boldest claim

The sentences

marginal significancep = 0.051so close (0.05 < p ≤ 0.1)

37 , 38 Moreover, variant carriers with AD exhibited higher levels of pTau217 with marginal significance ( p = 0.051; Figure 3E ), and higher levels of biomarkers indicating increased inflammation (i.e., CHI3L1, CCL13, IL33, and IL17A) compared to non‐carriers with AD.

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