Genome-wide association study provides novel insight into the genetic architecture of severe obesity.

PLoS Genet · 2025 · PMC12443252 · PMID 40939575

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extremely significantno p-value reported

We showed extremely significant concordance rates between the UK Biobank and GIANT BMI meta-analysis with our SevO GWAS results across all three P value thresholds in both the meta-analysis ( S18 Table ) and top COJO 714 BMI signals ( S19 Table ) indicating a strong enrichment of susceptibility alleles across traits.

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