Integrative analysis of single-cell and microarray data reveals SPI1-centered macrophage regulatory signatures in ulcerative colitis.

Differences were considered statistically significant at P < 0.05 and highly significant at P < 0.01. 3 Results 3.1 Single-cell clustering reveals UC-associated remodeling of cellular composition Although the two scRNA-seq datasets were derived from partially overlapping regions of the gut, we independently analyzed each dataset and observed a consistent increase in macrophage proportions in UC samples ( Supplementary Figure S12 ).

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