Frailty and stroke: Global implications for assessment, research, and clinical care-A WSO scientific statement.

Some studies have reported a non-significant relationship with stroke severity (National Institutes of Health Stroke Scale, NIHSS) on multivariable analysis, though there was a trend toward significance. 21 , 33 In contrast, other studies report an association that remained significant on multivariable analysis. 34 In a cohort of lacunar strokes, those with severe frailty were approximately 2.5-times more likely to have a severe stroke than individuals with non-severe frailty. 35 Other studies in ischemic strokes of embolic etiology have also reported a significant but weak association between FI and NIHSS. 14 These disparate findings may reflect the different methods of assessing frailty, limited sample size, and heterogeneous controlling for bias.

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