Magnitude and contributing factors responsible for premature greying of hair: A cross-sectional study.

On unadjusted analysis (Table 2 - see PDF), PGH was significantly associated with male sex (χ 2 = 6.2, p = 0.012), ever-smoking (χ 2 = 18.9, p < 0.001), high perceived stress (χ 2 = 10.7, p = 0.001), vitamin B12 deficiency (χ 2 = 25.4, p < 0.001), low ferritin, and positive family history (χ 2 = 56.3, p < 0.001). Multivariable logistic regression (Table 3 - see PDF) retained five independent predictors: family history (aOR 3.5), smoking ≥10 pack-years (aOR 2.1), vitamin B12 deficiency (aOR 2.8), high stress (aOR 1.9) and sub-clinical hypothyroidism (aOR 1.6, borderline significance).

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