Silica Nanoparticles Induced Epithelial-Mesenchymal Transition in BEAS-2B Cells via ER Stress and SIRT1/HSF1/HSPs Signaling Pathway.

J Xenobiot · 2025 · PMC12452771 · PMID 40981348

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The results found that the E-cadherin gene showed a decreasing trend with the increasing doses of SiNPs, while MMP-3 and Twist showed an increasing trend with the increasing doses ( Figure 4 B), suggesting that SiNPs might induce a decrease in intercellular adhesion and the subsequent acquisition of mesenchymal cell markers, leading to the development of EMT.

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