Sensitization of cancer cells to DNA-damaging agents by expression of the REV1 C-terminal domain: Implications for chemotherapy.

Proc Natl Acad Sci U S A · 2025 · PMC12452859 · PMID 40928869

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highly significantno p-value reported

Translesion synthesis (TLS) was one of the last recognized fundamental molecular mechanisms by which cells cope with DNA damage ( 1 , 2 ) and has subsequently been found to play multiple highly significant roles in biology, including cancer development and therapeutic responses.

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