Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG.

Oncogene · 2025 · PMC12454143 · PMID 40914769

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a decreasing trendno p-value reported

For the co-culture, the number of 2000 μm 2 or larger aggregates (cluster count) peaked at 6 h, then plateaued before a decreasing trend after 24 h.

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highly significantno p-value reported

Genes found to be highly significant in the unsupervised analysis were input into The Broad Institute CMap (clue.io) for gene set testing against the latest version of the L1000 dataset (CMAP LINCS 2020) containing over 3 million gene expression profiles.

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