Distinct lung functional, histological and cell senescence signatures in the single and repetitive bleomycin mouse models of idiopathic pulmonary fibrosis.

Physiol Rep · 2025 · PMC12455146 · PMID 40985117

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borderline significancep = 0.08so close (0.05 < p ≤ 0.1)

Contrasting histological findings of persistent lung fibrosis, the repetitive BLEO‐IPF mouse exhibited transient lung functional impairment, with only FEV0.1 being significantly reduced at 8 weeks compared to baseline, and static compliance (lung elasticity) showing borderline significance ( p = 0.08) toward impairment compared to CTRL.

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