Anti-oxidative stress therapies prevent severe chemotherapy-induced peripheral neuropathy in colorectal cancer patients treated with oxaliplatin: a systematic review and meta-analysis.

Front Oncol · 2025 · PMC12457107 · PMID 41001014

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highly significantno p-value reported

However, if we remove the study that tested metformin ( 36 ) from the antioxidant group meta-analysis, we still see a highly significant protective effect at the end of treatment ( Supplementary Figure 3 ).

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