Global burden of disease among adolescents and young adults with drug use disorders, 1990-2021: based on GBD 2021.

Front Public Health · 2025 · PMC12460290 · PMID 41018753

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a decreasing trendno p-value reported

Results Globally, the ASIR of new DUD cases among adolescents and young adults exhibited a decreasing trend from 1990 to 2021, with an EAPC of −0.46 (95% confidence interval: −0.52, −0.39).

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an increasing trendno p-value reported

The above two SDI regions demonstrated an increasing trend from 1990 to 2021.

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highly significantno p-value reported

This aligns with the findings of the current study, which reveals that regions with high SDI bear the greatest burden of DUDs and exhibit a highly significant increasing trend, while regions with low SDI carry the least burden.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.