Benchmarking genetic interaction scoring methods for identifying synthetic lethality from combinatorial CRISPR screens.

A Fisher’s exact test on the resulting contingency table yields a highly significant P -value (<2.2 × 10 −16 ), with an odds ratio of 144.72, indicating a strong concordance between the two benchmarks in SL classification.

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The difference between enabling or disabling orientation in Orthrus primarily affects the associated P- values—for example, a gene pair A-B may be significant, while B-A may not be.

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