an increasing trendP = .0085
ITS analysis indicated that ADENO positivity, which had been decreasing by 0.56% per year prepandemic (95% CI, 0.40%–0.72%; P < .0001), reversed to an increasing trend of +1.0% per year postemergence (95% CI, 0.28%–1.7%; P = .0085; for trend change, P = .0003; Figure 3 , Supplementary Table 4 ).