Composite endpoints in health technology assessment: Part 2 - expanding the evidence base with a framework for best modeling practice.

Notably, although the treatment effect on CV death was not significant in both DELIVER and EMPEROR-preserved, the numerical value of the treatment effect was comparable in both trials, and when pooled by class, the endpoint almost reached statistical significance, suggesting the lack of a significant treatment effect is likely due to insufficient power of the individual studies [ 13 ].

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