Consequently, the current available data imply that there may be significant translational value for the G10 peptide or similar PAR1:PAR3-derived bitopic polypeptides for a variety of pathologies where APC has provided beneficial therapy in a variety of preclinical animal studies [ 1 , 2 , 3 ].
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A Bivalent Protease-Activated Receptor-Derived Peptide Mimics Neuronal Anti-Apoptotic Activity of Activated Protein C.
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