Obesity/Overweight as a Meaningful Modifier of Associations Between Gene Polymorphisms Affecting the Sex Hormone-Binding Globulin Content and Uterine Myoma.

Interestingly, some loci, strongly linked with UM-causal SNP rs17496332 (A/G) PRMT6 , were fairly significant (GWAS information) for both SHBG level -tied sex hormone (total testosterone [rs12406721/r 2 = 0.86, D′ = 0.93 [ 42 , 43 ]) and lipid metabolism (HDL cholesterol [rs2878349/r 2 = 0.98, D′ = 1.00] [ 69 ], LDL cholesterol [rs111232683/r 2 = 0.86, D′ = 0.93] [ 70 ], BMI [rs12046439/r 2 = 0.49, D′ = 0.89] [ 71 , 72 , 73 ]).

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