Phytochemicals from <i>Euclea natalensis</i> Modulate Th17 Differentiation, HIV Latency, and Comorbid Pathways: A Systems Pharmacology and Thermodynamic Profiling Approach.

The resulting network comprised 308 nodes and 3649 edges, with an average node degree of 23.7, a local clustering coefficient of 0.494, and a highly significant PPI enrichment p -value < 1.0 × 10 −16 , indicating robust protein–protein associations beyond random expectation ( Figure S2 ).

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