Effect and Mechanism of Qihua Tongtiao Formula (QHTTF) on Improving Glucose and Lipid Metabolism Disorders in ZDF Rats by Integrating Network Pharmacology, Metabolomics, and Biological Validation.

However, body weight loss showed a notable trend in the Met group, while that of the QHTTF group was slightly reduced but not statistically significant ( p > 0.05), indicating that the herbal medicine has limited efficacy in reducing body weight and alleviating obesity in ZDF rats.

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However, the change trend in food intake were not apparent relative to the model after QHTTF and metformin interventions, while a decreasing trend in water consumption was observed, particularly at the 4th and 8th weeks ( Figure 4 C,D).

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