Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs.

Pharmaceutics · 2025 · PMC12472881 · PMID 41012491

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a slight trendno p-value reported

Furthermore, the AFE and AFFE were estimated at 1.48 and 1.63, respectively, for the predicted plasma exposure, suggesting a slight trend of overprediction, while remaining within the requirements for satisfactory model performance.

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