highly significantp ≤ 0.001
Statistical significance was determined as follows: p > 0.05 (nonsignificant, ns), p ≤ 0.05 (significant, *), p ≤ 0.01 (highly significant, **), p ≤ 0.001 (extremely significant, ***), and p ≤ 0.0001 (extremely significant, ****). 3.