Therapeutic potential of 5HT2CR in alleviating spasticity and pain via modulation of motor neurons and interneurons in spinal cord injury.

22 In our previous studies, a finding that piqued our interest, we used adeno-associated virus (AAV) to overexpress neurotrophin-3 (NT-3) and insulin-like growth factor-1 (IGF-1) in SCI rats, which alleviated hindlimb spasticity and showed an increasing trend in 5HT2CR expression. 23 Therefore, in this study, we evaluated the effects of overexpressing 5HT2CR in motor neurons, inhibitory interneurons, and excitatory interneurons.

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Conversely, the Vglut-2 group showed an increasing trend in the mean intensity of GABAAR and a decreasing trend in the mean intensity of KCC2 compared to the SCI group ( Figures 4 E and 4F).

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