highly significantp < 0.0001
Regarding HR ( Figure 4A ), a marked and highly significant decrease with age was observed during the first 12 months ( p < 0.0001; r = − 0.833), followed by a relative stabilization during adulthood characterized by a slight increase up to 120 months ( p < 0.0001; r = 0.084), and then another moderate increase between 120 and 220 months ( p < 0.0001; r = 0.300).