Immune Cells Mediate the Causal Pathway Linking Multisite Chronic Pain to Asthma: A Mediation Mendelian Randomization Study.

J Pain Res · 2025 · PMC12478215 · PMID 41030774

Europe PMC DOI

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highly significantP = 7.23 × 10 −52actually significant

The LDSC analysis confirmed positive and highly significant genetic correlations between CP phenotypes and asthma (MCP, rg = 0.44, P = 7.23 × 10 −52 ; knee pain, rg = 0.37, P = 8.25 × 10 −7 ; back pain, rg = 0.35, P = 3.45 × 10 −10 ; neck/shoulder pain, rg = 0.36, P = 1.26 × 10 −5 ; stomach/abdominal pain, rg = 0.50, P = 5.40×10 −7 ).

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