Effects of NSAIDs on Early CKD Development: A 10-Year Population-Based Study Using the Korean Senior Cohort.

1–1.93), but no statistically significant association was found in unmatched cohort (HR 1.15; 95% CI 0.91–1.46) (Table 2 .) Users of the NSAIDs demonstrated a more rapid loss of eGFR, especially during the first year, which was also confirmed by Kaplan–Meier survival curve analysis, demonstrating a highly significant higher incidence of CKD (Fig. 1 ) The subgroup analysis indicated that both Cox-1 and Cox-2 inhibitors raised the risk of CKD with hazard ratios of 1.53 (95% CI 1.16–2.01) and 1.61 (95% CI 1.16–2.23), respectively (Supplementary Tables S2 and S3).

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