Furthermore, in DKD patients at different stages, there is a positive correlation between kidney lipid droplets and the albumin excretion rate (AER) 15 ; a highly significant correlation between the increased expression of lipogenic genes, including LDLR, CD36 and SCD1, and the progression of human DKD and a decrease in the eGFR; and a highly significant negative correlation between the expression of fatty acid oxidation genes, including PPARα and CPT1, and the eGFR 13 .
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Prolonged glucagon exposure rewires lipid oxidation and drives diabetic kidney disease progression.
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