Multiomic Mendelian randomization analysis of metabolic gene methylation expression and protein levels in lung adenocarcinoma.

Discov Oncol · 2025 · PMC12480298 · PMID 41021077

Europe PMC DOI

hedged sentences

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closest p · 1.0× alpha

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boldest claim

The sentences

marginal significanceP < 0.05actually significant

Excluding associations with a P-HEIDI of less than 0.01, 2729 CpG sites associated with 1254 genes met the threshold for marginal significance ( P < 0.05).

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highly significantno p-value reported

Conversely, HYKK exhibited a highly significant reduction in risk (OR 0.016, 95% CI 0.004–0.07, PPH4 0.916), indicating a potent influence on reducing LUAD risk.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.