Local homeostasis preserves global neural dynamics compensating for structural loss during human lifespan aging.

Increased functional integration, as observed from an increasing trend in global efficiency and average characteristic path length in older groups (see Fig. 3 i, j), might be associated with the compensatory process against the decline in structural integration (Fig. 3 c, d), which enhances the communicability or the ability to combine technical information from distributed cortical circuits.

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Structural integration 26 declines with age as suggested by a decreasing trend in global efficiency 14 and significantly decreased characteristic path length (Fig. 3 c, d) in elderly subjects.

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