Temporal nutrition analysis associates dietary regularity and quality with gut microbiome diversity: insights from the Food & You digital cohort.

Moreover, when we fit a model using daily HEI instead of the regular HEI score (with age and BMI as continuous variables and without any interaction terms), daily HEI remained a highly significant predictor of Shannon entropy ( β = 0.019, p < 0.001, 95% CI [0.0141, 0.0242])) (Supplementary Table 3 ), reflecting an even stronger effect than the standard HEI coefficient would have shown in that same model ( β = 0.013, p < 0.001, 95% CI [0.0085, 0.0179]).

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