marginally significantP < 0.05
While considering the changes in tremor severity for both left and right hands (by taking the average change in tremor severity) for a given tremor phase combination derived from instantaneous tremor phases from both hands, both patients showed multiple phase combinations that provided marginally significant effects on bilateral tremor severity (Fig. 2E,I , blue stars, P < 0.05 against surrogate distribution, although none of them survived multiple comparison corrections).