highly significantP < 0.01
P values were considered significant when * P < 0.05 and highly significant when ** P < 0.01, *** P < 0.001, and **** P < 0.0001.
P values were considered significant when * P < 0.05 and highly significant when ** P < 0.01, *** P < 0.001, and **** P < 0.0001.