High-order single-nucleotide polymorphism interactions between selected anti-oxidant and protease genes influence North Indians' propensity for chronic obstructive pulmonary disease (COPD) and lung function parameters.

Hum Genomics · 2025 · PMC12487100 · PMID 41029839

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0.0002

closest p · 0.0× alpha

0.0002

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The sentences

highly significantp = 0.0002actually significant

Logistic regression revealed that the individuals with the homozygous mutant genotype ( GG ) show a substantial 2-fold increased likelihood of developing COPD, a highly significant result ( p = 0.0002, FDR = 0.002).

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